Jay Steinberg.jpg

Jay Steinberg, MD

Lab Years: 2001-2003

Fellowship: Cardiothoracic Surgery

                                Penn State

(Critical Care Lab) Publications:

1.       Schiller HJ, McCann UG, Carney DE, Gatto LA, Steinberg JM, Nieman GF. Altered alveolar mechanics in the acutely injured lung. Crit Care Med. 2001;29(5):1049-1055.


2.       Carney DE, McCann UG, Schiller HJ, Gatto LA, Steinberg JM, Picone AL, Nieman GF. Metalloproteinase inhibition prevents acute respiratory distress syndrome. J Surg Res. 2001. 99;245-252.


3.       McCann UG, Schiller HJ, Carney DE, Gatto LA, Steinberg JM, Nieman GF. Visual validation of the mechanical stabilizing effects of PEEP at the alveolar level (Mechanical Stabilizing effects of PEEP). J Surg Res. 2001. 99;335-342.


4.       Steinberg JM, Fink G, Picone A, Searles B, Schiller H, Lee HM, Nieman GF. Evidence of increased matrix metalloproteinase-9 concentration and activity in patients following cardiopulmonary bypass. J Extracorporal Tech. 2001. 33:218-222.


5.      Steinberg JM, Schiller HJ, Gatto LA, Nieman GF. Stabilizing Alveoli With Positive End-Expiratory Pressure (PEEP) Reduces Lung Injury. Surgical Forum. 2001. 52:198-199.


6.      McCann UG, Schiller HJ, Gatto LA, Steinberg JM, Carney DE, Nieman GF. Alveolar mechanics alter hypoxic pulmonary vasoconstriction. Crit Care Med. 2002. 30(6):1315-1321.


7.      Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Dasilva M, Amato M, McCann UG, Nieman GF. Tidal volume increase do not affect alveolar mechanics in normal lung but cause alveolar over-distension and exacerbate alveolar instability following surfactant deactivation. Crit Care Med. 2002. 30:2675-2683.


8.      Darling E, Searles B, Nasrallah F, Robins M, You X, Gatto LA, Clay N, Picone A, Steinberg JM, Nieman GF. High-volume balanced ultra-filtration improves pulmonary function in a model of post-pump syndrome. J Am Extra-Corp Tech. 2002. 34:254-259.


9.      Halter JM, Steinberg JM, Schiller HJ, DaSilva M, Gatto LA, Landas S, Nieman GF. Positive end-expiratory pressure (PEEP) after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Resp Crit Care Med. 2003. 167:1620-1626.


10.      Schiller HJ, Steinberg J, Halter JM, McCann UG, Dasilva M, Gatto LA, Carney DE, Nieman GF. Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung. Crit Care Med. 2003. 31:1126-1133.


11.      Steinberg JM, Halter JM, Schiller HJ, DaSilva, Landas S, Gatto LA, Maisi P, Sorsa T, Rajamaki M, Lee H-M, Nieman GF. Metalloproteinase inhibition reduces lung injury and improves survival following cecal ligation and puncture in rats. J Surg Res. 2003. 111:185-195.


12.      Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Lee H-M, Pavone LA, Nieman GF. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. Am J Resp Crit Care Med. 2004;169:57-63.


13.      Steinberg JM, Halter JM, Schiller H, Gatto LA, Nieman GF. The development of acute respiratory distress syndrome model after gut ischemia/reperfusion injury followed by fecal peritonitis in pigs: A clinically relevant model. Shock. 2005;23: 129-137.


14.      Steinberg JM, Schiller H, Tsvaygenbaum B, Mahoney G, DiRocco J, Gatto LA, Nieman GF. Wood smoke inhalation causes alveolar instability in a dose dependent fashion. Resp Care. 2005;50:1062-1070.


15.      Steinberg JM, Halter JM, Schiller H, Gatto LA, Carney DE, Lee H-M, Golub L, Nieman GF. Chemically-modified tetracycline (COL-3) prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model. Shock. 2005;24:348-356.


16.      Swartz MF, Halter JM, Fink G, Pavone LA, Zaitsev A, Lee H-M, Steinberg JM, Lutz CJ, Sorsa T, Gatto LA, Landas S, Hare C, Jalife J, Nieman GF. Chemically-Modified Tetracycline Improves Contractility in Porcine Coronary Ischemia/Reperfusion Injury. J Cardiac Surgery. 2006;21:254-260.


17.      Halter JM, Steinberg JM, Fink G, Lutz CJ, Maybury R, Fedors N, DiRocco J, Lee H-M, Nieman GF. Evidence of Systemic Cytokine Release in Patients Undergoing Cardiopulmonary Bypass. J Extra Corpor Technol. 2006 Sep;37(3):272-7.


18.      Halter JM, Pavone LA, Steinberg JM, Gatto LA, DiRocco J, Landas S, Nieman GF. Chemically modified tetracycline (COL-3) improves survival if given 12 but 24 hours after cecal ligation and puncture. Shock. 2006;26:587-591.


19.      Halter JM, Steinberg JM, Gatto LA, DiRocco J, Picone, LA, Schiller HJ, Albert SP, Lee H-M, Carney DE, Nieman GF. Effect of Positive End-expiratory Pressure (PEEP) and Tidal Volume on Alveolar Instability-Induced Lung Injury. Crit Care. 2007;11 (1):R20.